Evaluation of genes involved in the demethylation pathway revealed 6 of 10 AID/APOBEC genes were increased in the mesenchymal subtype of glioblastoma (Figure 7A and Table S4), whereas 2 of 5 BER genes were increased in the mesenchymal subtype of glioblastoma compared to the proneural subtype (Figure 7A and Table S4). This evidence concerns the gene AICDA and glioblastoma.