However, complementary to the quantitative atherosclerosis en face results in particular after 24 weeks on the WTD, the SRA-TGF-ß1 ApoE−/− double-mutant mice with macrophage-specific TGF-ß1 overexpression showed multiple significant differences in terms of plaque composition compared to ApoE−/− controls. This evidence concerns the gene APOE and atherosclerosis.