S. aureus enterotoxin B (SEB) shifts the cytokine pattern further in nasal polyps toward T-helper-2 cytokines (increases interleukin-2, interleukin-4, and interleukin-5 greater than twofold), but it reduces the T-regulatory cytokines interleukin-10 and TGF-beta1. The gene discussed is SETBP1; the disease is nasal cavity polyp.