We here provide evidence, that exposure of nonprofessional host cells (tumor cells) to Staphylococci stimulates the canonical WIPI-1 response at the onset of autophagy, which is to bind to PtdIns(3)P at the phagophore to foster the recruitment of downstream ATGs, such as Atg5 and LC3 [9, 32]. The gene discussed is ATG5; the disease is neoplasm.