Several lines of evidence suggest that regulation of the level of sialylation is a powerful mechanism to control the surface charge of channels as well as neuronal channel pathology [27, 43–45]: for example, long QT syndrome (LQT, a cardiac disease relate to HERG) is also caused by the mutation of glycosylated sites in HERG [45]. Here, KCNH2 is linked to Prolonged QT interval.