ACE and Hyperglycemia: Another study reported similar results in ZOF rats, where not only insulin and glucose but all metabolic parameters including LDL, HLD, and triglycerides as well as oxidative stress and vascular dysfunction were significantly improved in response to ACE inhibition (enapril); however, these parameters were not improved nearly as much in the Zucker diabetic fatty rat (ZDF), indicating that overt hyperglycemia is more resistant to Ang II inhibition [139].