Increased expression and activity of the phagocytic NAD(P)H oxidases with a parallel increase of oxidized LDL (oxLDL) and nitrotyrosine levels accompanied by thickened intima to media ratio in the carotid arteries, indicative of early subclinical atherosclerosis, have been demonstrated in metabolic syndrome patients [13]. The gene discussed is FMO5; the disease is metabolic syndrome.