Therefore, the positive effects of ACE inhibitors and ARBs in the cardiovascular system, apart from lowering blood pressure thereby reducing hypertrophic vascular remodeling and afterload on the heart, can likely be attributed to their direct antioxidant effects as well as reduction in blood glucose and associated benefits, most notably reduction in AGEs and associated vascular remodeling (decreased compliance) and improvement in the lipid profile, specifically HDL levels, which tend to correlate with oxLDL, apparently the most predictive factor for CAD development. The gene discussed is ACE; the disease is coronary artery disorder.