In addition a number of naturally occurring compounds including selenite, curcumin, digitoxin, dietary flavonoids and the green-tea constituent EGCG inhibit TOP2 or induce TOP2-DNA complexes in cell culture studies [29,30,31,32,33,34] and it has been suggested that flavonoids and catechins derived from the maternal diet may contribute to in utero MLL translocations underlying neonatal leukemias through their activity as topoisomerase poisons II [29,30,35,36]. This evidence concerns the gene KMT2A and leukemia.