Returning to the MLL gene, the similar distribution of t-AL and neonatal acute lymphoblastic leukemia MLL translocation breakpoints [44] is intriguing since MLL translocations are particularly common in infant acute leukemia [46] and it has been suggested that TOP2 poisons acting in utero may play a role in the etiology of infant leukemias [30,35,44,47]. This evidence concerns the gene KMT2A and acute leukemia.