INS and type 2 diabetes mellitus: GCKR has been associated with metabolic and inflammatory traits including triglyceride concentrations and other lipid fractions [30], [32], fasting plasma glucose [33], [34], insulin concentrations, uric acid, c-reactive protein (CRP), and non-alcoholic fatty liver disease which are all characteristic of the metabolic syndrome and T2D [28], [35], [36], [37], [38], [39], [40], [41], [42].