Similarly, Sensenbrenner and Jeune syndromes appear to be milder presentations of the embryonically lethal short rib polydactyly syndrome as IFT80, WDR35 and DYNC2H1 are mutated in both milder and more severe phenotypes [22, 28, 54, 57, 61]. This evidence concerns the gene DYNC2H1 and Jeune syndrome.