Excitingly, high-throughput tandem affinity purifications for “nephrocystins” and “Meckel–Gruber-associated proteins” have recently been executed in ciliated cells, and have indeed proven to facilitate gene identification when combined with clinical SNP microarray data from families with ciliopathies; mutations in ATXN10 and TCTN2 were recently identified as the cause of nephronophthisis and Joubert syndrome through this combination of methods [14]. Here, TCTN2 is linked to Joubert syndrome.