Evidence linking block of T- and R-type calcium channels to analgesia can be surmised from the work of Dickenson and colleagues who reported that the CaV2.3 antagonist SNX-482 reduces primary afferent-mediated dorsal horn neuronal responses in a rat model of chronic neuropathic pain (spinal nerve ligation) [8] and Li and colleagues who reported that intrathecal administration of the T-type channel blocker mibefradil suppresses thermal hyperalgesia and allodynia in the chronic compression of dorsal root ganglion (CCD) model of neuropathic pain [53]. The gene discussed is CACNA1E; the disease is Pain.