Dopamine agonists significantly reduced prolactin level (WMD, -45; 95% CI, -77 to -11) and the risk of persistent hyperprolactinemia (RR, 0.9; 95% CI, 0.81 to 0.99) but not other patient-important outcomes (Additional file 1: Figures 2A and 2B). Here, PRL is linked to hyperprolactinemia.