The immune cells from pulchellin-treated mice also produced statistically higher concentrations of TNF-α by PEC cells, and IL-4, IFN-γ and IL-10 by splenocytes, and lower concentrations of IL-6 (PEC cells) and TGF-β (splenocytes), than the cells from tumor control mice (Figures 2 and 3). Here, TNF is linked to neoplasm.