IL6 and cardiovascular disorder: Enhanced levels of circulating leucocytes, pro-inflammatory cytokines (e.g., IL-6, TNF-α, IL-1β) and CRP have been associated with an increased risk of cardiovascular disease and type 2 diabetes in long-term human and experimental studies.141–144 Increased plasma levels of IL-6 were reported after partial and total sleep deprivation in most cases,93,106,107,108,112 although two studies only reported a loss of circadian rhythms82,96 (Table 1).