Transforming Growth Factor β (TGFβ) signalling is one of the best characterized pathways in carcinogenesis and a dual role is observed with a tumor suppressing effect during cancer initiation phase followed by a tumor-promoting effect associated with EMT in more advanced cancer when the Ras /PI3K/ akt pathway is often concomitantly activated and p53 is mutated or disabled [19]. The gene discussed is TP53; the disease is neoplasm.