FN1 and muscle tissue disorder: Relative to baseline, their individual gene expression analysis of day 21 revealed significant differential expression of genes such as collagens, fibronectin and matrix metalloproteinase, etc. Interestingly, such genes are involved in biological categories such as Genetic disorder, Skeletal and muscular disorder, Protein Synthesis, Cell morphology, Connective tissue development, and Cellular development, which were all significant sets according to our analysis (Additional file 2: Table S2).