STAT5B and immunodeficiency disease: Other immunodeficiencies strongly associated with AI manifestations comprise immune dysregulation, polyendocrinopathy, enteropathy X-linked (IPEX) syndrome, autoimmune polyendocrine syndrome type 1, combined immunodeficiencies (CID) including hypomorphic severe (S)CID variants (Liston et al., 2008), both calcium channelopathies, Wiskott–Aldrich syndrome (WAS), DiGeorge syndrome, Good syndrome, activation-induced deaminase (AID) deficiency, CD25 deficiency, Stat5b deficiency, and cartilage hair dysplasia (Al-Herz et al., 2011).