NFATC2 and Wiskott-Aldrich syndrome: In particular, TCR-dependent nuclear recruitment of Nuclear Factor of Activated T cells (NFAT)-1 in CD4+ T cells and both NFAT-1 and NFAT-2 in CD8+ T cells are reduced in WAS patients and correlate with defective Th1 cytokine production (Cianferoni et al., 2005; Trifari et al., 2006).