In addition, administration of the GSK3 inhibitor 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (TDZD-8) or GSK3β haploinsufficiency rescue enhanced ‘anxiety’ and ‘behavioural despair’ phenotypes in 5-HT-deficient R439H tph2 knockin mice [25]. The gene discussed is GSK3B; the disease is Anxiety.