There were in total 27 menin positive tumors out of 38 (71.0%), of these, 26 out of 38 (68.4%) cases expressed menin in the cytoplasm of tumor cells (c-menin) with a mean value of positive tumor cells of 44.7±6.1 (mean ± SE) and 3 out of 38 (7.9%) tumors, two of which were also c-menin positive, showed specific nuclear immunoreactivity for menin (n-menin) (2.3±2.1). This evidence concerns the gene MEN1 and neoplasm.