MEN1 and neoplasm: Furthermore, the mutational study of MEN1 gene, associated with the IHC analysis of menin indicated that tumors displaying MEN1 nucleotide variant were characterized by a higher accumulation of menin in the cytoplasm and, for our knowledge, this strong association between MEN1 variants and cytoplasmic localization of menin has not been previously reported in sporadic pulmonary carcinoids, thus representing an interesting finding for this type of tumor.