In addition, patients with LOHF are defined as those showing prothrombin time values of ≤40 % of the standardized value or INRs of 1.5 or more and grade II or more severe hepatic coma between 8 and 24 weeks of the onset of the disease symptoms, and those without histological evidence of hepatitis are also included in the disease entity of LOHF, similar to the case of acute liver failure. Here, F2 is linked to acute liver failure.