For instance searching for loops containing the oncogene HRAS (ENSG00000174775), identifies a coherent feedforward loop potentially suppressing HRAS where miR-892a directly suppresses HRAS and, indirectly, suppresses HRAS by suppressing the oncogene PLAG1, a putative activator of HRAS. miRNA deregulation of PLAG1 is already known to occur in leukemia cells [55], thus there is a possibility HRAS may in some circumstances be a downstream effector of miR-892a and PLAG1. This obviously needs further experimental investigation to verify the predicted regulatory links. This evidence concerns the gene HRAS and leukemia.