Notably, aging was characterized by widespread upregulation of all MHC II subtypes (DP alpha, DP beta, DQ alpha, DQ beta, DR alpha, DR beta, HLA-DMA, HLA-DMB) across the four brain regions (Additional file 7: Table S7A), with continued upregulation of many of these genes in AD, particularly in the EC, PCG and SFG (Additional file 7: Table S7B). Here, SRPRA is linked to Alzheimer disease.