In addition, the majority of studies investigating brain Al3+ concentrations did not detect concentrations exceeding 10 μg/g brain mass (dry weight) in AD brains [54], which approximately corresponds to 60 μmol/kg (wet weight), while many studies examining the influence of Al3+ on tau aggregation in vitro applied Al3+ concentrations in the milimolar range [25,27,55]. Here, MAPT is linked to Alzheimer disease.