Previous reports reviewed that p38 and p44/42 MAPKs may play a critical role in harmful microglial activation in acute brain injury [50]; JNK is activated by proinflammatory cytokines and cellular stress, and play essential roles in regulating inflammatory responses [51,52]; activation of MAPK entities, especially Erk and p38, is a determinant of neuronal survival on certain occasions [53-55]; and, selective inhibitors (PD98059 and SB203580) are candidates for treatment [48,49]. This evidence concerns the gene MAPK8 and brain injury.