CRP and rheumatoid arthritis: The aim of this study was to examine the impact of cigarette smoking and alcohol drinking habits on markers of systemic inflammation, such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), total serum Ig levels and immune response following pneumococcal vaccination using 7-valent pneumococcal conjugate vaccine in patients with RA and SpA treated with different anti-inflammatory remedies.