Doses of everolimus that produced an antitumor effect in a syngeneic CA20948 pancreatic rat tumor xenograft model also dramatically inhibited mTOR signaling (as measured by inhibition of 4E-BP1 phosphorylation and S6K1 signaling) in tumor, skin, and peripheral blood mononuclear cells (PBMCs)[10]. This evidence concerns the gene MTOR and neoplasm.