Mutations in TFs and ERs are not major events in chronic myeloid leukemia (CML), which is triggered by the BCR-ABL1 fusion; however, mutations in ERs such as ASXL1, IDH1/2 and TET2 may participate to CML progression to AML [113,114]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.