In this study, the infection with F4ab ETEC slightly down-regulated the mRNA levels of FUT1 (FC = −1.35, P < 0.001, NM_214068) and MUC13 (FC = −2.24, P = 0.088, NM_001105293) in the IPEC-J2 cells, while in the F4ac ETEC infected IPEC-J2 cells, the down-regulated genes included: FUT1 (FC = −1.62, P < 0.001, NM_214068), MUC4 (FC = −3.36, P < 0.05, ENSSSCT00000012962), MUC13 (FC = −3.00, P < 0.01, NM_001105293) and MUC20 (FC = −1.33, P < 0.05, NM_001113440). Here, FUT1 is linked to infection.