Another study demonstrated that injection of fms-like tyrosine kinase 3 ligand (Flt3L) encoding adenoviruses in tumor-bearing mice resulted in the increase of spleen DC, T, B lymphocytes and NK cells but also of MDSC which dominated and blocked anti-tumor activity of effector cells (Solheim et al., 2007). Here, FLT3LG is linked to neoplasm.