CYBB and neoplasm: The increase production of ROS has emerged as one of the main features of MDSC in tumor-bearing mice and cancer patients (Bronte et al., 2000; Schmielau and Finn, 2001; Mantovani et al., 2003; Szuster-Ciesielska et al., 2004; Kusmartsev et al., 2005; Agostinelli and Seiler, 2006; Youn et al., 2008), partly through NOX2 activity (Corzo et al., 2009).