In addition, MMP8 downregulation in non-metastatic cells increases their metastatic potential (Montel et al., 2004; Gutierrez-Fernandez et al., 2008), and high MMP8 levels in human carcinomas correlate with lower metastasis incidence and a better prognosis to patients with breast or oral cancer (Decock et al., 2007; Korpi et al., 2008). Here, MMP8 is linked to lip and oral cavity carcinoma.