In fact, several well established models display morphological and behavioral alterations in some, but not all domains (e.g., disrupted in schizophrenia-1 (DISC-1), neuregulin-1 (NRG-1), NMDA receptor subunit 1 (NR1) or catechol-o-methyltransferase (COMT); (for review, see: Gainetdinov et al., 2001; O'Tuathaigh et al., 2007; Kellendonk et al., 2009; Jaaro-Peled et al., 2010; Lu et al., 2011). Here, COMT is linked to schizophrenia.