In addition, nuclear fractionation (Fig 4A) and staining of cleaved (activated) caspase 3 and caspase-cleaved cytokeratin-18 (Fig 4B and C, respectively) indicated that cannibalism led to the apoptosis of the engulfed cells (and occasionally of the cannibals), again similar to our observations in human tumours. The gene discussed is CASP3; the disease is neoplasm.