TGFB1 and neoplasm: Dedifferentiation of malignant cells is achieved through the epithelial-to-mesenchymal transition (EMT), a crucial milestone of tumour development and metastasis triggered by the transforming growth factor β (TGFβ) (Cano et al, 2010; Thiery et al, 2009; Truty & Urrutia, 2007).