PDX1 and pancreatic neoplasm: Finally, in order to establish the pivotal role of Nupr1 in the repression of HoCC in vivo, we investigated whether Nupr1-deficiency resulted in more cell-in-cells in pancreatic tumours developed by the Pdx1-creER; LSL-KRASG12D; INK4A/ARFfl/fl mice (Bardeesy et al, 2006; Gu et al, 2002).