The biglycan-induced inflammasome activation was found to be of considerable relevance invivo in two mouse models of sterile renal inflammation (UUO and Murphy Roths Large[MRL]/lpr lupus nephritis) and in the prototypic pathogen-mediatedsystemic inflammation of LPS-induced sepsis (Babelova et al. 2009; Moreth et al. 2010). The gene discussed is BGN; the disease is lupus nephritis.