In this regard, haploinsufficiency of Ranbp2 confers neuroprotection to photoreceptor neurons upon light-elicited oxidative stress [31, 32], whereas semi-dominant mutations in human RANBP2 promote the rampant necrosis of basal ganglia neurons triggered by febrile states and viral infections of multiple etiologies [33]. The gene discussed is RANBP2; the disease is viral infectious disease.