We observed that PIP expression was consistently reduced following the inhibition of AR-ERK signaling with a fold-change of 0.19 to 0.71 in MDA-MB-453 cell line and 0.26 to 0.65 in HCC-1954 line compared to the control groups (Table 2 and Figure 1B). The gene discussed is AR; the disease is hepatocellular carcinoma.