Several aspects of HAE-C1-INH (hereditary transmission, improper diagnosis, unpredictability of attacks, disabling symptoms, risk of fatal attacks, unnecessary surgeries, inadequate treatments, frequent need for emergency intervention, lack of information about the disease among health care professionals, adverse effects of treatment or unavailability of specific treatment, etc.)could diminish HRQoL, and the impact of HAE-C1-INH on quality of life should be evaluated. This evidence concerns the gene SERPING1 and hereditary angioedema.