For example, four genes (i.e., GRB2, HDAC1, HDAC2, and TP53) identified in the chronic myeloid leukemia pathway are known to be distinguish AML from ALL, indicating that other genes in this module might also be potential biomarkers for AML. The gene discussed is GRB2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.