The long term effect of the combined strategy on lung development after hyperoxic exposure still remains to be studied Also the effect of Antileukinate on the immune response and changing the susceptibility of neonates to infection after short and long term treatment approach has to be studied However, we suggest that combination of EC-SOD supplementation and neutrophil blockade can prevent hyperoxia-induced lung injury and may offer an important therapeutic strategy that can protect lung development in premature newborns at risk of developing BPD. This evidence concerns the gene SOD1 and bronchopulmonary dysplasia.