Some linkage studies [3] ascribe an important role to genes such as ELAC2 (elaC homolog 2 (E. coli)) at 17q, RNASEL at 1q24–25 (Hereditary Prostate Cancer gene 1 (HPC1)) [4], and MSR1 (macrophage scavenger receptor 1) at 8p22, which contain inactivating mutations in affected members in at least one prostate cancer family. The gene discussed is MSR1; the disease is prostate cancer.