Treatment with EGFR-specific siRNAs of different EGFR-TKI resistant NSCLC cell lines expressing wild-type EGFR resulted in reduced proliferation of the cells [9], [10], [11], [12] indicating that EGFR-TKI resistance and EGFR independence are at least not always equivalent. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.