The significance of chemokines (CCL2 [monocyte chemotactic protein-1], CCL5 [RANTES] and CX3CL1 [fractalkine]) and their receptors (CCR2, CCR5 and CX3CR1) in atherosclerosis has been demonstrated in animal models and clinical studies [8]–[10]. The gene discussed is CX3CR1; the disease is atherosclerosis.