To elucidate molecular mechanisms of decreased susceptibility to colitis-associated colon carcinogenesis in Neu3-deficient mice, we analyzed EGFR signaling in colon mucosa of DSS-treated mice as described previously [22], because EGFR signaling is involved both in colitis-associated colon carcinogenesis [40] and NEU3-induced formation of ACF [22]. The gene discussed is NEU3; the disease is colitis.