All the AOM-treated mice developed ACF, and the Neu3 deficiency did not affect the ACF numbers (wild-type vs. KO: 41.8±3.8 vs. 40.0±11.4, n = 4/group, Fig. S2A) or multiplicity (wild-type vs. KO: 2.0±1.0 vs. 2.2±1.0, data not shown). This evidence concerns the gene NEU3 and infectious otitis media.