NEU3 and colon adenocarcinoma: All the mice treated with AOM/DSS developed colon adenocarcinoma (Fig. 4), but the number of adenocarcinomas per mouse was significantly lower in the Neu3-deficient mice than in the wild-type mice (Fig. 3C, p = 0.037), suggesting NEU3 is involved in colitis-associated colon carcinogenesis.