PRDX2 and cancer: ALDH has been reported to play an important role in cancer therapeutics; it can decrease the effectiveness of some anticancer drugs, such as cyclophosphamide and ifosfamide, by detoxifying their major active aldehyde metabolites [25]; PRDX2 encodes a member of the peroxiredoxin family of antioxidant enzymes, which play important roles in maintaining the intracellular redox homeostasis.