Binding predictions for Ag85B-ESAT-6, Ag85B-TB10.4, and Mtb72f were generated for 34 HLA-DRB1 alleles representing the three most common DRB1 alleles in each of the populations in the Allele*Frequencies in Worldwide Populations databank from the 22 countries with the highest burden of TB as identified by the WHO [24], [25]. The gene discussed is HLA-DRB1; the disease is tuberculosis.