CD8A and infection: To examine the impact and possible compensatory effects of IL-12 and type I IFN as signal 3 to CD8 T cell responses in the context of infections, P14 T cells that lack either the type I IFN receptor (P14.IFNARKO), the IL-12 receptor (P14.IL-12RKO) or both (P14.DOKO) were adoptively transferred in B6 recipient mice.