In light of possible combined effects from different variants or genotypes and potential interactions of PTEN/AKT/mTOR gene polymorphism on the risk of PCa, we then combined the two SNPs based on the number of the putative risk allele (rs2295080 T and rs7254617 G allele which appeared to be statistically associated with an increased risk of PCa). Here, AKT1 is linked to posterior cortical atrophy.