PPP1R8 and neoplasm: Given that (1) NIPP1 is expressed in cervix and also in HeLa and PC-3-M cells derived from cervical and prostate tumours, respectively [67], (2) NIPP1 levels are tightly linked to malignant phenotype in tumours [68], (3) NIPP1 levels and its association to PP1 control directional cell migration, this suggests that an upregulation of PP1/NIPP1 is expected to reverse the “default” cathodal polarization (towards the lumen) and encourage invasion of the surrounding tissue (Fig. 7).