Based on the increased frequency and activation profile of NK and T cells effectors in the tumor following MDSC depletion, we evaluated apoptosis of tumor cells by quantifying the expression of cleaved caspase 3 by IHC in the tumor sections and the % of annexin V/PI +ve stained cells on the non CD45 expressing tumor cell population by flow cytometric analysis. This evidence concerns the gene ANXA5 and neoplasm.