IHC of the tumor sections revealed increased tumor staining of cleaved caspase 3 (Figure 4A) and increased % of annexin V/PI +ve apoptotic tumor cells (early: 2.5–5.9 fold, late: 1.9–2.4 fold) (Figure 4B) in the MDSC depleted groups compared to controls. The gene discussed is ANXA5; the disease is neoplasm.