Since PGE2 contributes to tumor progression by EGFR signal amplification, through receptor transactivation [11]–[13], and by the activation of tumor angiogenesis [21]–[23], we measured EGFR phosphorylation and the angiogenic output in tumor explants taken at day 10 and in A431 cells exposed to IL-1 β (10 ng/ml) in the presence of AF3485 (10 μM) (Fig. 3B). This evidence concerns the gene EGFR and neoplasm.