IGHE and allergic disease: Interestingly, while viral, bacterial and protozoan infections can skew the immune response away from a Th2-dominated CD4+ T cell response – which underlies the development of allergy – acute (or early) helminth infection, in contrast, can favor Th2 responses with production of IL-4, IL-5 and IL-13 and large amounts of pro-allergenic IgE [17].